The ketogenic diet has recently come under scientific scrutiny for its potential to combat neurodegenerative diseases, particularly Alzheimer’s. A groundbreaking study using mice models suggests that this high-fat, low-carbohydrate diet could slow the progression of cognitive decline associated with Alzheimer’s. Researchers are particularly interested in the diet’s ability to increase beta-hydroxybutyrate (BHB) molecules, which have been linked to protection against neuroinflammation\u2014a key contributor to Alzheimer’s disease.<\/p>\n
Despite these promising findings in mice, there is a clear need for human studies. The pathology of Alzheimer’s in mice does not fully replicate the complexity of the human condition, thus making it difficult to ascertain if the same effects would be observed in people. However, the study, which involved genetically modified APP\/PS1 mice, an established model of Alzheimer’s disease, has certainly paved the way for further exploration. These mice, when placed on a ketogenic diet, showed a delayed onset of Alzheimer’s symptoms compared to those on a standard diet.<\/p>\n
BHB is not only seen in mice; it’s also present in humans and associated with delaying the onset of mild cognitive dementia. Produced during the body’s fat burning process for energy, BHB feeds the mitochondria, the powerhouses of the cells. Interestingly, a study by UC Davis previously found BHB’s anti-inflammatory effects on human brain cells, suggesting a potential therapeutic avenue for neuroinflammation-related conditions.<\/p>\n
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